Statins and acute lung injury
نویسندگان
چکیده
منابع مشابه
Additional experimental evidence that statins protect against acute lung injury.
1. Muscedere J, Rewa O, McKechnie K, Jiang X, Laporta D, Heyland DK. Subglottic secretion drainage for the prevention of ventilator-associated pneumonia: a systematic review and meta-analysis. Crit Care Med 2011;39(8):1985-1991. 2. Poelaert J, Depuydt P, De Wolf A, Van de Velde S, Herck I, Blot S. Polyurethane cuffed endotracheal tubes to prevent early postoperative pneumonia after cardiac surg...
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Acute lung injury (ALI) is a devastating clinical condition associated with pulmonary and systemic inflammation and characterized by incompetence of the pulmonary microvascular barrier culminating in noncardiogenic pulmonary edema. An understanding of the mechanisms underlying endothelial barrier dysfunction in ALI has been facilitated by study of the effects of statins in relevant cellular and...
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Introduction: One ofdiagnostic criteria for Acute Lung Injury and Acute Respiratory Distress Syndrome is pao2/fio2 (PF) ratio 300 for ALI or 200 for ARDS. This criteria requires invasive arterial sampling. Measurement of Spo2/Fio2 (SF) ratio by pulseoximetry may be a reliable non invasive alternative to the PF ratio. Methods and Materials: In a cross sectional study we enrolled 105 sample o...
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Hepatic hydroxymethyl glutaryl–CoA reductase inhibitors, known as statins, are among the most commonly prescribed drugs in the world. Scientists studying microorganism host defense first identified statins in the 1970s. They were eventually shown in large randomized trials, such as the Scandinavian Simvastatin Survival Study and the West of Scotland Coronary Prevention Study, to confer substant...
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ژورنال
عنوان ژورنال: Critical Care Medicine
سال: 2012
ISSN: 0090-3493
DOI: 10.1097/ccm.0b013e3182451fb2